Pale toadstool (Amanita phalloides) is the most poisonous mushroom in the world. The search for an antidote to it has been going on for a long time, but Chinese scientists seem to have finally come close to the solution.
Pale toadstool poisoning, according to some data, is the cause of 90% of deaths due to mushroom consumption.
Chinese researchers used the CRISPR gene editing method to search for chemicals that could neutralize the poison of this mushroom.
They found that alpha-amanthine (the most potent toadstool venom toxin) has the greatest effect on the STT3B protein. The team set out to find a substance that could block the interaction between alpha-amantine and STT3B.
As a result of long experiments, they found a substance called indocyanine green (ICG).
This is a cyan dye that is used in medical diagnostics. It is used to determine cardiac output, liver function, hepatic and gastric blood flow, as well as for ophthalmic and cerebral angiography.
The scientists tested their hypothesis on mice and found that half of those poisoned with the poison of the pale toadstool survived after the infusion of indocyanine.
In the future, the researchers want to expand on their findings by verifying the safety and efficacy of ICG. If this happens, humanity will finally have an antidote to the poison of the most dangerous mushroom in the world.
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